Ontology highlight
ABSTRACT:
SUBMITTER: Beato M
PROVIDER: S-EPMC6729805 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Beato Marco M Groot-Kormelink Paul J PJ Colquhoun David D Sivilotti Lucia G LG
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040101 4
The glycine receptor mediates fast synaptic inhibition in the spinal cord and brainstem. Its activation mechanism is not known, despite the physiological importance of this receptor and the fact that it can serve as a prototype for other homopentameric channels. We analyzed single-channel recordings from rat recombinant alpha1 glycine receptors by fitting different mechanisms simultaneously to sets of sequences of openings at four glycine concentrations (10-1000 microm). The adequacy of the mech ...[more]