Patterns of gene expression reveal a temporally orchestrated wound healing response in the injured spinal cord.

ABSTRACT: Spinal cord injury (SCI) induces a progressive pathophysiology affecting cell survival and neurological integrity via complex and evolving molecular cascades whose interrelationships are not fully understood. The present experiments were designed to: (1) determine potential functional interactions within transcriptional expression profiles obtained after a clinically relevant SCI and (2) test the consistency of transcript expression after SCI in two genetically and immunologically diverse rat strains characterized by differences in T cell competence and associated inflammatory responses. By interrogating Affymetrix U34A rat genome GeneChip microarrays, we defined the transcriptional expression patterns in midcervical contusion lesion sites between 1 and 90 d postinjury of athymic nude (AN)

SUBMITTER: Velardo MJ 

PROVIDER: S-EPMC6729887 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature