The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring.
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ABSTRACT:
SUBMITTER: Van Epps HA
PROVIDER: S-EPMC6729946 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Publications
The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring.
Van Epps Heather A HA Hayashi Mitsuko M Lucast Louise L Stearns George W GW Hurley James B JB De Camilli Pietro P Brockerhoff Susan E SE
The Journal of neuroscience : the official journal of the Society for Neuroscience 20041001 40
Visual, vestibular, and auditory neurons rely on ribbon synapses for rapid continuous release and recycling of synaptic vesicles. Molecular mechanisms responsible for the properties of ribbon synapses are mostly unknown. The zebrafish vision mutant nrc has unanchored ribbons and abnormal synaptic transmission at cone photoreceptor synapses. We used positional cloning to identify the nrc mutation as a premature stop codon in the synaptojanin1 (synj1) gene. Synaptojanin 1 (Synj1) is undetectable i ...[more]
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