Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
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SUBMITTER: Compan V
PROVIDER: S-EPMC6729986 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
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Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
Compan Valérie V Zhou Mingming M Grailhe Régis R Gazzara Russell A RA Martin Renee R Gingrich Jay J Dumuis Aline A Brunner Daniela D Bockaert Joël J Hen René R
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040101 2
To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, sugge ...[more]
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