Ontology highlight
ABSTRACT:
SUBMITTER: Takei N
PROVIDER: S-EPMC6730227 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Takei Nobuyuki N Inamura Naoko N Kawamura Mihoko M Namba Hisaaki H Hara Kenta K Yonezawa Kazuyoshi K Nawa Hiroyuki H
The Journal of neuroscience : the official journal of the Society for Neuroscience 20041101 44
In neurons, perisynaptic or dendritic translation is implicated in synapse-wide alterations of function and morphology triggered by neural activity. The molecular mechanisms controlling local translation activation, however, have yet to be elucidated. Here, we show that local protein synthesis and translational activation in neuronal dendrites are upregulated by brain-derived neurotrophic factor (BDNF) in a rapamycin and small interfering RNA specific for mammalian target of rapamycin (mTOR)-sen ...[more]