Ontology highlight
ABSTRACT:
SUBMITTER: Dreyer J
PROVIDER: S-EPMC6730309 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
The Journal of neuroscience : the official journal of the Society for Neuroscience 20041101 46
Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), the major source of nitric oxide (NO) in the nervous system, are not completely understood. We report here a protein-protein interaction between nNOS and NOSIP (nitric oxide synthase-interacting protein) in rat brain in vivo. NOSIP and nNOS are concentrated in neuronal synapses and demonstrate significant colocalization in various regions of the central and peripheral nervous systems. NOSIP produces a significant reducti ...[more]