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BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia.

ABSTRACT: Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.

SUBMITTER: Jin J

PROVIDER: S-EPMC6730603 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia.

Jin Jingxia J Luo Shuna S Ye XingNong X Huang Jian J

OncoTargets and therapy 20190902

Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same tim ...[more]

PMID: 31564896

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