Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC6731069 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Jiayang J Shi Kejian K Sabet Zeinab Farhadi ZF Fu Wenjiao W Zhou Huige H Xu Shaoxin S Liu Tao T You Min M Cao Mingjing M Xu Mengzhen M Cui Xuejing X Hu Bin B Liu Ying Y Chen Chunying C
Science advances 20190906 9
Carbonic anhydrase (CA) IX overexpresses exclusively on cell membranes of hypoxic tumors, regulating the acidic tumor microenvironment. Small molecules of CA inhibitor modified with short peptide successfully achieve CA IX-targeted self-assembly that localizes CA inhibitors on hypoxic cancer cell surfaces and enhances their inhibition efficacy and selectivity. CA IX-related endocytosis also promotes selective intracellular uptake of these nanofibers under hypoxia, in which nanofiber structures i ...[more]