Ontology highlight
ABSTRACT:
SUBMITTER: Harney DJ
PROVIDER: S-EPMC6731089 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Harney Dylan J DJ Hutchison Amy T AT Su Zhiduan Z Hatchwell Luke L Heilbronn Leonie K LK Hocking Samantha S James David E DE Larance Mark M
Molecular & cellular proteomics : MCP 20190715 9
Unbiased and sensitive quantification of low abundance small proteins in human plasma (<i>e.g.</i> hormones, immune factors, metabolic regulators) remains an unmet need. These small protein factors are typically analyzed individually and using antibodies that can lack specificity. Mass spectrometry (MS)-based proteomics has the potential to address these problems, however the analysis of plasma by MS is plagued by the extremely large dynamic range of this body fluid, with protein abundances span ...[more]