Ontology highlight
ABSTRACT:
SUBMITTER: Katsuda T
PROVIDER: S-EPMC6731094 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Katsuda Takeshi T Matsuzaki Juntaro J Yamaguchi Tomoko T Yamada Yasuhiro Y Prieto-Vila Marta M Hosaka Kazunori K Takeuchi Atsuko A Saito Yoshimasa Y Ochiya Takahiro T
eLife 20190808
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed. We recently reported that mature rodent hepatocytes can be reprogrammed into progenitor-like cells with a repopulative capacity using small molecule inhibitors. Here, we demonstrate that hepatic progenitor cells can be obtained from human infant hepatocytes using the same strategy. ...[more]