Ontology highlight
ABSTRACT:
SUBMITTER: Whicher JR
PROVIDER: S-EPMC6731095 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Whicher Jonathan R JR MacKinnon Roderick R
eLife 20190906
Voltage-gated potassium channels (K<sub>v</sub>s) are gated by transmembrane voltage sensors (VS) that move in response to changes in membrane voltage. K<sub>v</sub>10.1 or Eag1 also has three intracellular domains: PAS, C-linker, and CNBHD. We demonstrate that the Eag1 intracellular domains are not required for voltage-dependent gating but likely interact with the VS to modulate gating. We identified specific interactions between the PAS, CNBHD, and VS that modulate voltage-dependent gating and ...[more]