Ontology highlight
ABSTRACT:
SUBMITTER: Porter SN
PROVIDER: S-EPMC6731097 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Porter Shaina N SN Magee Jeffrey A JA
Experimental hematology 20170606
Acute myeloid leukemia (AML) cells often co-opt normal hematopoietic stem cell (HSC) programs to drive neoplastic proliferation, and HSC-related gene expression signatures have been identified as biomarkers for poor prognosis in AML patients. We sought to identify new regulators of HSCs and AML cells from previously published HSC and leukemia stem cell (LSC) gene expression signatures. We identified PRKCH (protein kinase C eta) as a gene that is highly expressed in both mouse and human HSCs, as ...[more]