Ontology highlight
ABSTRACT:
SUBMITTER: Gilles ME
PROVIDER: S-EPMC6731108 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Gilles Maud-Emmanuelle ME Hao Liangliang L Brown Kaelyn K Lim Jihoon J Bhatia Sangeeta N SN Slack Frank J FJ
Oncotarget 20190903 51
Developing new targeted therapy for pancreatic cancer is one of the major current challenges in cancer research. KRAS mutations and miRNA dysregulation (e.g. miR-21-5p oncomiR) play key roles in Pancreatic Ductal Adenocarcinoma (PDAC), leading to rapid progression of the disease. As the KRAS mutation is a main driver of PDAC, anti-KRAS strategies remain a major therapeutic approach for PDAC treatment. Previously, utilization of either siKRAS or small chemically modified single-stranded RNA molec ...[more]