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Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF.


ABSTRACT: High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function of FF-HDL is associated with fertility outcomes. From 253 women undergoing modified natural cycle (MNC)- IVF at a single academic centre FF and plasma were collected (n?=?375 cycles). Anti-oxidative function of FF was mainly attributable to HDL (n?=?8; 83%). FF-HDL had a higher anti-oxidative function than plasma HDL (n?=?19, P?

SUBMITTER: Nagy RA 

PROVIDER: S-EPMC6731220 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF.

Nagy Ruxandra A RA   van Montfoort Aafke P A APA   Groen Henk H   Homminga Irene I   Andrei Daniela D   Mistry Rima H RH   Anderson Josephine L C JLC   Hoek Annemieke A   Tietge Uwe J F UJF  

Scientific reports 20190906 1


High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function of FF-HDL is associated with fertility outcomes. From 253 women undergoing modified natural cycle (MNC)- IVF at a single academic centre FF and plasma  ...[more]

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