Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC6731242 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhao Bo B Lin Jianhuang J Rong Lijie L Wu Shuai S Deng Zhong Z Fatkhutdinov Nail N Zundell Joseph J Fukumoto Takeshi T Liu Qin Q Kossenkov Andrew A Jean Stephanie S Cadungog Mark G MG Borowsky Mark E ME Drapkin Ronny R Lieberman Paul M PM Abate-Shen Cory T CT Zhang Rugang R
Nature communications 20190906 1
ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis. ARID1A promotes the expression of cohesin subunit STAG1 that is specifically required for telomere cohesion. ARID1A inactivation causes telomere damage that can be rescued by STAG1 expression. Colony form ...[more]