Ontology highlight
ABSTRACT:
SUBMITTER: Gemperlein K
PROVIDER: S-EPMC6731297 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Gemperlein Katja K Dietrich Demian D Kohlstedt Michael M Zipf Gregor G Bernauer Hubert S HS Wittmann Christoph C Wenzel Silke C SC Müller Rolf R
Nature communications 20190906 1
Long-chain polyunsaturated fatty acids (LC-PUFAs), particularly the omega-3 LC-PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), have been associated with beneficial health effects. Consequently, sustainable sources have to be developed to meet the increasing demand for these PUFAs. Here, we demonstrate the design and construction of artificial PUFA biosynthetic gene clusters (BGCs) encoding polyketide synthase-like PUFA synthases from myxobacteria a ...[more]