Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC6731303 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yang Ying Y Li Ziming Z Yuan Hong H Ji Wenxiang W Wang Kaixuan K Lu Tingting T Yu Yongfeng Y Zeng Qingyu Q Li Fan F Xia Weiliang W Lu Shun S
Oncogenesis 20190906 9
MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, and metastasis. However, the regulatory mechanism between miRNAs and FGFR1 in lung cancer remains unclear and extremely critical. miR-214-3p was sharply decreased and showed a significantly negative correlation with FGFR1 in lung cancer patients (n = 30). Luciferase reporter assay confirmed that miR-214-3p could downregulate FGFR1 by directly t ...[more]