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Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination.


ABSTRACT: Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory ('original antigenic sin'), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus-naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations.

SUBMITTER: Bradt V 

PROVIDER: S-EPMC6731309 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination.

Bradt Victoria V   Malafa Stefan S   von Braun Amrei A   Jarmer Johanna J   Tsouchnikas Georgios G   Medits Iris I   Wanke Kerstin K   Karrer Urs U   Stiasny Karin K   Heinz Franz X FX  

NPJ vaccines 20190906


Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory ('original antigenic sin'), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF va  ...[more]

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