MiR-876-3p targets KIF20A to block JAK2/STAT3 pathway in glioma.
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ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC6731397 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
MiR-876-3p targets KIF20A to block JAK2/STAT3 pathway in glioma.
Tang Jiao J Xu Jie J Zhi Zhongwen Z Wang Xiang X Wang Yu Y Zhou Yong Y Chen Rui R
American journal of translational research 20190815 8
Aberrant expression of miRNAs has been reported to be involved in the development and progression of glioma. But the function of miR-876-3p in glioma is unknown. We found that miR-876-3p is significantly downregulated in glioma tissues and cell lines. Overexpression of miR-876-3p suppressed glioma cell proliferation, epithelial-mesenchymal transition, migration, and invasion. By prediction combining with luciferase reporter assay, we identified that miR-876-3p could decrease the expression of KI ...[more]
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