Ontology highlight
ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC6731436 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hu Juanjuan J Jiang Caiying C Zheng Meijun M Guo Yuxin Y Tang Xin X Ren Jia J Lu Dan D Yu Lingyu L Gan Weigang W Liu Shixi S Tong Aiping A Yang Hui H
American journal of translational research 20190815 8
Head and neck cancers (HNCs) are the sixth most common type of cancer in the world. Despite the development of refined surgical techniques and precise targeted radiation, patients with HNCs have a dismal prognosis. Here, we examine the expression profile of B7-H3 in HNCs and verify whether B7-H3 can serve as a novel therapeutic target for HNCs via anti-B7-H3×CD3 bispecific antibodies (biAbs). We analyzed the expression level of B7-H3 in 274 HNC samples and evaluated the association between B7-H3 ...[more]