Ontology highlight
ABSTRACT:
SUBMITTER: Sie C
PROVIDER: S-EPMC6731453 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Sie Christopher C Perez Laura Garcia LG Kreutzfeldt Mario M Potthast Maria M Ohnmacht Caspar C Merkler Doron D Huber Samuel S Krug Anne A Korn Thomas T
Journal of immunology (Baltimore, Md. : 1950) 20190809 6
Homing of pathogenic CD4<sup>+</sup> T cells to the CNS is dependent on α4 integrins. However, it is uncertain whether α4 integrins are also required for the migration of dendritic cell (DC) subsets, which sample Ags from nonlymphoid tissues to present it to T cells. In this study, after genetic ablation of <i>Itga4</i> in DCs and monocytes in mice via the promoters of <i>Cd11c</i> and <i>Lyz2</i> (also known as LysM), respectively, the recruitment of α4 integrin-deficient conventional and plasm ...[more]