Ontology highlight
ABSTRACT:
SUBMITTER: McCormick B
PROVIDER: S-EPMC6731454 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
McCormick Barry B Craig Helen E HE Chu Julia Y JY Carlin Leo M LM Canel Marta M Wollweber Florian F Toivakka Matilda M Michael Melina M Astier Anne L AL Norton Laura L Lilja Johanna J Felton Jennifer M JM Sasaki Takehiko T Ivaska Johanna J Hers Ingeborg I Dransfield Ian I Rossi Adriano G AG Vermeren Sonja S
Journal of immunology (Baltimore, Md. : 1950) 20190819 6
Neutrophils are abundant circulating leukocytes that are rapidly recruited to sites of inflammation in an integrin-dependent fashion. Contrasting with the well-characterized regulation of integrin activation, mechanisms regulating integrin inactivation remain largely obscure. Using mouse neutrophils, we demonstrate in this study that the GTPase activating protein ARAP3 is a critical regulator of integrin inactivation; experiments with Chinese hamster ovary cells indicate that this is not restric ...[more]