A coarse-grained model of the expansion of the human rhinovirus 2 capsid reveals insights in genome release.
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ABSTRACT:
SUBMITTER: Indelicato G
PROVIDER: S-EPMC6731498 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
A coarse-grained model of the expansion of the human rhinovirus 2 capsid reveals insights in genome release.
Indelicato Giuliana G Cermelli Paolo P Twarock Reidun R
Journal of the Royal Society, Interface 20190814 157
Human rhinoviruses are causative agents of the common cold. In order to release their RNA genome into the host during a viral infection, these small viruses must undergo conformational changes in their capsids, whose detailed mechanism is strictly related to the process of RNA extrusion, which has been only partially elucidated. We study here a mathematical model for the structural transition between the native particle of human rhinovirus type 2 and its expanded form, viewing the process as an ...[more]
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