Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann JW
PROVIDER: S-EPMC6731550 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hofmann Jeffrey W JW Seeley William W WW Huang Eric J EJ
Annual review of pathology 20181024
Frontotemporal dementia is a group of early onset dementia syndromes linked to underlying frontotemporal lobar degeneration (FTLD) pathology that can be classified based on the formation of abnormal protein aggregates involving tau and two RNA binding proteins, TDP-43 and FUS. Although elucidation of the mechanisms leading to FTLD pathology is in progress, recent advances in genetics and neuropathology indicate that a majority of FTLD cases with proteinopathy involving RNA binding proteins show ...[more]