Ontology highlight
ABSTRACT:
SUBMITTER: Akera T
PROVIDER: S-EPMC6731994 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Akera Takashi T Trimm Emily E Lampson Michael A MA
Cell 20190808 5
Asymmetric division in female meiosis creates selective pressure favoring selfish centromeres that bias their transmission to the egg. This centromere drive can explain the paradoxical rapid evolution of both centromere DNA and centromere-binding proteins despite conserved centromere function. Here, we define a molecular pathway linking expanded centromeres to histone phosphorylation and recruitment of microtubule destabilizing factors, leading to detachment of selfish centromeres from spindle m ...[more]