Dysregulation of N6-methyladenosine regulators predicts poor patient survival in mantle cell lymphoma.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6732954 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Dysregulation of N<sup>6</sup>-methyladenosine regulators predicts poor patient survival in mantle cell lymphoma.
Zhang Weilong W He Xue X Hu Jing J Yang Ping P Liu Cuiling C Wang Jing J An Ran R Zhen Jingfei J Pang Meng M Hu Kai K Ke Xiaoyan X Zhang Xiuru X Jing Hongmei H
Oncology letters 20190802 4
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m<sup>6</sup>A during B-cell development and B-cell tumorigenesis remains poorly understood. By analyzing the gene expression profile of 123 mantle cell lymphoma cases from the Gene Expression Omnibus database, the present study demonstrated that on ...[more]
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