Dataset Information

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.

ABSTRACT: Background: The association between vitamin D receptor (VDR) polymorphisms and the risk of asthma remains unclear. This study aimed to investigate the effect of VDR gene polymorphisms and VDR mRNA expression levels on respiratory function, nitric oxide levels in expiratory air, and serum vitamin D levels in children with asthma. Materials and Methods: The study included 80 healthy children (control group) and 100 asthmatic children (asthma group) between the age of 5 and 18 years. The VDR genotypes (ApaI, TaqI, and FokI) and VDR mRNA levels were determined in all groups. Results: There was no statistically significant difference in vitamin D levels between the asthma group and the control group (P?>?0.05). A significant association was found between both genotype (CC) of the TaqI polymorphism [odds ratio (OR)?=?0.2, 95% confidence interval (CI) (0.07-0.5), P?=?0.003] and genotype (CA) of ApaI polymorphisms [OR?=?0.2, 95% CI (0.07-0.8), P?=?0.02], and asthma risk. In addition, when single-nucleotide polymorphism allelic frequencies between asthma and control groups were compared there is no significant association (P?>?0.05). When compared to control group, VDR mRNA expression in asthma group decreased in genotypes CC and CA of ApaI and in genotypes TT and TC of TaqI (P?

SUBMITTER: Kilic M

PROVIDER: S-EPMC6733045 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.

Kilic Mehmet M Ecin Sema S Taskin Erdal E Sen Askin A Kara Murat M

Pediatric allergy, immunology, and pulmonology 20190617 2

Background: The association between vitamin D receptor (VDR) polymorphisms and the risk of asthma remains unclear. This study aimed to investigate the effect of VDR gene polymorphisms and VDR mRNA expression levels on respiratory function, nitric oxide levels in expiratory air, and serum vitamin D levels in children with asthma. Materials and Methods: The study included 80 healthy children (control group) and 100 asthmatic children (asthma group) between the age of 5 ...[more]

PMID: 31508258

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Project description:BackgroundGestational diabetes mellitus (GDM) increased risk of perinatal complications for both the women and the fetuses. The association between the vitamin D receptor (VDR) gene polymorphism and GDM has not been thoroughly investigated in Chinese pregnant women. Therefore, we aimed to determine whether VDR gene single nucleotide polymorphisms (SNPs) rs154410, rs7975232, rs731236, rs2228570 and rs739837 contribute to GDM risk in Wuhan, China. Moreover, we aimed to explore their combined effects on the risk of GDM.MethodsPregnant women who had prenatal examinations at 24 to 28 weeks' gestation in our hospital from January 15, 2018 to March 31, 2019 were included in this case-control study. After exclusion, a total of 1684 pregnant women (826 GDM patients and 858 non-diabetic controls) were recruited. The clinical information and blood samples were collected by trained interviewers and nurses. Genotyping of candidate SNPs was conducted on the Sequenom MassARRAY platform. Statistical analyses including t-test, ANOVA, chi-square test and logistic regression were performed to the data with SPSS Software to evaluate differences in genotype distribution and associations with GDM risk. Multifactor dimensionality reduction method was used to explore the gene-gene interactions on the risk of GDM.ResultsDifferences in age, pre-pregnancy BMI, family history of diabetes and previous history of GDM between the case and control groups were statistically significant (P?<?0.05), whereas no significant differences were found in height, gravidity, parity, and age of menarche (P?>?0.05). There were no significant differences at genotype distributions of the examined VDR gene SNPs (P?>?0.05). After adjusting by age, pre-pregnancy BMI, family history of diabetes, the results of logistic regression analysis showed no associations of the five SNPs with GDM in all the four genotype models(P?>?0.05). Furthermore, there were no gene-gene interactions on the GDM risk among the five examined VDR gene SNPs.ConclusionsThe VDR gene SNPs rs154410, rs7975232, rs731236, rs2228570 and rs739837 showed neither significant associations nor gene-gene interactions with GDM in Wuhan, China.

Dataset Information

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.

Publications

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.

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