Shaping of infant B cell receptor repertoires by environmental factors and infectious disease.
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ABSTRACT:
SUBMITTER: Nielsen SCA
PROVIDER: S-EPMC6733608 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Shaping of infant B cell receptor repertoires by environmental factors and infectious disease.
Nielsen Sandra C A SCA Roskin Krishna M KM Jackson Katherine J L KJL Joshi Shilpa A SA Nejad Parastu P Lee Ji-Yeun JY Wagar Lisa E LE Pham Tho D TD Hoh Ramona A RA Nguyen Khoa D KD Nguyen Khoa D KD Tsunemoto Hannah Y HY Patel Sonal B SB Tibshirani Robert R Ley Catherine C Davis Mark M MM Parsonnet Julie J Boyd Scott D SD
Science translational medicine 20190201 481
Antigenic exposures at epithelial sites in infancy and early childhood are thought to influence the maturation of humoral immunity and modulate the risk of developing immunoglobulin E (IgE)-mediated allergic disease. How different kinds of environmental exposures influence B cell isotype switching to IgE, IgG, or IgA, and the somatic mutation maturation of these antibody pools, is not fully understood. We sequenced antibody repertoires in longitudinal blood samples in a birth cohort from infancy ...[more]
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