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Spontaneous breathing during extracorporeal membrane oxygenation treatment of sickle cell disease acute chest syndrome.

ABSTRACT: Sickle cell disease (SCD) is a hereditary hemoglobinopathy resulting in sickling hemoglobin. Acute chest syndrome (ACS) is a serious complication of SCD and an important cause of morbidity and mortality. Management of ACS is complex and may necessitate mechanical ventilation and veno-venous extracorporeal membrane oxygenation (VV-ECMO) therapy in the more severe cases. We present herein the case of a young female adult (19 y.o.) with SCD who developed severe respiratory failure due to ACS occurring twice within 15 months and treated by VV-ECMO. We describe the management of ACS with VV-ECMO using two different approaches, namely with and without mechanical ventilation.

SUBMITTER: Belveyre T

PROVIDER: S-EPMC6733779 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Spontaneous breathing during extracorporeal membrane oxygenation treatment of sickle cell disease acute chest syndrome.

Belveyre Thibaut T Auchet Thomas T Levy Bruno B

Respiratory medicine case reports 20190814

Sickle cell disease (SCD) is a hereditary hemoglobinopathy resulting in sickling hemoglobin. Acute chest syndrome (ACS) is a serious complication of SCD and an important cause of morbidity and mortality. Management of ACS is complex and may necessitate mechanical ventilation and veno-venous extracorporeal membrane oxygenation (VV-ECMO) therapy in the more severe cases. We present herein the case of a young female adult (19 y.o.) with SCD who developed severe respiratory failure due to ACS occurr ...[more]

PMID: 31516819

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