The effect of the source and the concentration of polymers on the release of chlorhexidine from mucoadhesive buccal tablets.

ABSTRACT: In the current work, two groups of chlorhexidine mucoadhesive buccal tablets were prepared, using either rod or irregularly-shaped spherical particles of hydroxypropyl methylcellulose and different ratios of poloxamer 407 (P407). The tablets were designed to release the drug over two hours. Their physicochemical properties and drug release profiles were investigated. The impact on dry granulation, the ex-vivo mucoadhesion, the swelling index, the morphology of swollen tablets and the drug release kinetic were investigated. Drug-polymers chemical interaction was studied using Fourier Transforms Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC). Due to different particle shapes, the preparation of dry granules required a 40 KN force for rod-shaped particles comp

SUBMITTER: Al-Ani E 

PROVIDER: S-EPMC6733786 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature