Ontology highlight
ABSTRACT:
SUBMITTER: Kimpo MS
PROVIDER: S-EPMC6733832 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Current oncology reports 20190910 10
<h4>Purpose of review</h4>We aim to review the most recent findings in the use of NK cells in childhood cancers.<h4>Recent findings</h4>Natural killer cells are cytotoxic to tumor cells. In pediatric leukemias, adoptive transfer of NK cells can bridge children not in remission to transplant. Interleukins (IL2, IL15) can enhance NK cell function. NK cell-CAR therapy has advantages of shorter life span that lessens chronic toxicities, lower risk of graft versus host disease when using allogeneic c ...[more]