Increased frequency of CD4⁺CD57⁺ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance.

ABSTRACT: Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57⁺ T cells in the CD4⁺ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients

SUBMITTER: Youn JC 

PROVIDER: S-EPMC6733929 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature