Ontology highlight
ABSTRACT:
SUBMITTER: Holmstrom SR
PROVIDER: S-EPMC6734175 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Holmstrom Sam R SR Wijayatunge Ranjula R McCrum Kelly K Mgbemena Victoria E VE Ross Theodora S TS
iScience 20190826
Both BRCA1 and CREBBP are tumor suppressor genes that are important for hematopoiesis. We have previously shown that mouse Brca1 is essential for hematopoietic stem cell (HSC) viability. In contrast to Brca1 deficiency, which results in pancytopenia, we report here that Crebbp deficiency results in myeloproliferation associated with an increase of splenic HSCs as well as a lethal systemic inflammatory disorder (LD50 = 86 days). To investigate the interaction of these two proteins in hematopoiesi ...[more]