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Ultra-high field MR angiography in human migraine models: a 3.0?T/7.0?T comparison study.


ABSTRACT: BACKGROUND:Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0?tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0?T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. METHODS:Five subjects completed two sessions at respectively 3.0?T and 7.0?T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. RESULTS:Standard deviations of arterial circumference revealed no difference between 3.0?T and 7.0?T measurements (p?=?0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p?

SUBMITTER: Christensen CE 

PROVIDER: S-EPMC6734314 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study.

Christensen Casper Emil CE   Younis Samaira S   Lindberg Ulrich U   Boer Vincent Oltman VO   de Koning Patrick P   Petersen Esben Thade ET   Paulson Olaf Bjarne OB   Larsson Henrik Bo Wiberg HBW   Amin Faisal Mohammad FM   Ashina Messoud M  

The journal of headache and pain 20190506 1


<h4>Background</h4>Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery.<h4>Methods</h4>Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography s  ...[more]

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