Ultra-high field MR angiography in human migraine models: a 3.0?T/7.0?T comparison study.

ABSTRACT: BACKGROUND:Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0?tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0?T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. METHODS:Five subjects completed two sessions at respectively 3.0?T and 7.0?T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. RESULTS:Standard deviations of arterial circumference revealed no difference between 3.0?T and 7.0?T measurements (p?=?0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p?

SUBMITTER: Christensen CE 

PROVIDER: S-EPMC6734314 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature