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Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control.


ABSTRACT: Long-range phase synchrony in the ?-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-? band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility required during set-shifting. Using electroencephalography (EEG) in 23 patients with focal frontal lobe lesions (resected tumors), we tested the hypothesis that the FP network is necessary for modulation of high-? band phase synchrony. Global phase-synchrony was measured using an adaptation of the phase-locking value (PLV) in a sliding window procedure, which allowed for measurement of changes in EEG-based resting-state functional connectivity across time. As hypothesized, the temporal modulation (range and standard deviation) of high-? phase synchrony was reduced as a function of FP network lesion extent, mostly due to dorsolateral prefrontal cortex (dlPFC) lesions. Furthermore, patients with dlPFC lesions exhibited reduced cognitive flexibility as measured by the Trail-Making Test (set-shifting). Our findings provide evidence that the FP network is necessary for modulatory control of high-? band long-range phase synchrony, and linked to cognitive flexibility.

SUBMITTER: Sadaghiani S 

PROVIDER: S-EPMC6735251 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control.

Sadaghiani Sepideh S   Dombert Pascasie L PL   Løvstad Marianne M   Funderud Ingrid I   Meling Torstein R TR   Endestad Tor T   Knight Robert T RT   Solbakk Anne-Kristin AK   D'Esposito Mark M  

Cerebral cortex (New York, N.Y. : 1991) 20190901 10


Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility  ...[more]

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