Dataset Information

The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.

ABSTRACT: The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Specifically, we designed a convolutional neural network (CNN) based classifier, which can differentiate gyral and sulcal fMRI signals with reasonable accuracies. Further investigations of learned CNN models imply that sulcal fMRI signals are more diverse and more high frequency than gyral signals, suggesting that gyri and sulci truly play different functional roles. These differences are significantly associated with axonal fiber wiring and cortical thickness patterns, suggesting that these differences might be deeply rooted in their structural and cellular underpinnings. Further wavelet entropy analyses demonstrated the validity of CNN-based findings. In general, our collective observations support a new concept that the cerebral cortex is bisectionally segregated into 2 functionally different units of gyri and sulci.

SUBMITTER: Liu H

PROVIDER: S-EPMC6735260 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.

Liu Huan H Zhang Shu S Jiang Xi X Zhang Tuo T Huang Heng H Ge Fangfei F Zhao Lin L Li Xiao X Hu Xintao X Han Junwei J Guo Lei L Liu Tianming T

Cerebral cortex (New York, N.Y. : 1991) 20190901 10

The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Specifically, we designed a convolutional neural network (CNN) based cla ...[more]

PMID: 30541110

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Dataset Information

The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.

Publications

The Cerebral Cortex is Bisectionally Segregated into Two Fundamentally Different Functional Units of Gyri and Sulci.

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