Patterns and Intensities of Near-Infrared and Short-Wavelength Fundus Autofluorescence in Choroideremia Probands and Carriers.

ABSTRACT:

Purpose

To ascertain cellular constituents within islands of preserved retina in choroideremia (CHM) by multimodal imaging.

Methods

CHM probands (16) and female carriers (9) of CHM were studied. Near-infrared autofluorescence (NIR-AF; 787-nm excitation; emission, >830 nm), short-wavelength autofluorescence (SW-AF; 488-nm excitation, 500- to 680-nm emission), and spectral-domain optical coherence tomography (SD-OCT) images were acquired with a confocal scanning laser ophthalmoscope. SW-AF intensities were measured by quantitative fundus autofluorescence (qAF), and NIR-AF intensity profiles were analyzed. Retinal thicknesses and visual acuity were measured.

Results

In 19 of 31 eyes of affected males, islands of preserved NIR-AF signal were also visible as fluorescence s

SUBMITTER: Paavo M 

PROVIDER: S-EPMC6735265 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature