Ontology highlight
ABSTRACT:
SUBMITTER: Lao K
PROVIDER: S-EPMC6735293 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lao Kejing K Xun Guoliang G Gou Xingchun X Xiang Hua H
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Prostate cancer (PCa) is the second leading cause of death in men. Apart from androgen receptor, 5α-reductase has also been recognized as a potential target. In this study, a series of androst-17β-amide compounds have been designed and synthesized targeting both AR and 5α-reductase. Their anti-proliferation activities were evaluated in AR + cell line 22RV1 and AR - cell line PC-3. The results indicated that most of the synthesized compounds inhibited the testosterone-stimulated cell proliferatio ...[more]