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Apixaban enhances endogenous fibrinolysis in patients with atrial fibrillation.


ABSTRACT: AIMS:Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants on endogenous fibrinolysis is unknown. Our aim was to test the hypothesis that apixaban enhances endogenous fibrinolysis in non-valvular atrial fibrillation (NVAF). METHODS AND RESULTS:In a prospective cross-sectional analysis, we compared endogenous fibrinolysis in NVAF patients (n?=?180) taking aspirin, warfarin, or apixaban. In a prospective longitudinal study, patients were tested before and after apixaban (n?=?80). Endogenous fibrinolysis was assessed using the Global Thrombosis Test (GTT) and thromboelastography (TEG). Endogenous fibrinolysis [measured by GTT lysis time (LT)] was shorter on apixaban compared with warfarin or aspirin [median 1850 (IQR 1591-2300) vs. 2758 (2014-3502) vs. 2135 (1752-2463) s, P?

SUBMITTER: Spinthakis N 

PROVIDER: S-EPMC6735819 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Apixaban enhances endogenous fibrinolysis in patients with atrial fibrillation.

Spinthakis Nikolaos N   Gue Ying Y   Farag Mohamed M   Srinivasan Manivannan M   Wellsted David D   Arachchillage Deepa R J DRJ   Lip Gregory Y H GYH   Gorog Diana A DA  

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20190901 9


<h4>Aims</h4>Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants on endogenous fibrinolysis is unknown. Our aim was to test the hypothesis that apixaban enhances endogenous fibrinolysis in non-valvular atrial fibrillation (NVAF).<h4>Methods and results</h4>In a prospective cross-sectional analysis, we compared endogenous fibrino  ...[more]

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