Ontology highlight
ABSTRACT:
SUBMITTER: Winnerdy FR
PROVIDER: S-EPMC6735952 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Winnerdy Fernaldo Richtia FR Bakalar Blaž B Maity Arijit A Vandana J Jeya JJ Mechulam Yves Y Schmitt Emmanuelle E Phan Anh Tuân AT
Nucleic acids research 20190901 15
Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous conformations of right-handed and a few left-handed G-quadruplexes were previously observed, yet they were always identified separately. Here, we present the NMR solution and X-ray crystal structures of a right- and left-handed hybrid G-quadruplex. The structure reveals a stacking interaction between two G-quadruplex blocks with different helical orie ...[more]