Syphilis Reactivates Latent Epstein-Barr Virus Reservoir via Toll-Like Receptor 2 and B-Cell Receptor Activation.
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ABSTRACT:
SUBMITTER: Hirsiger JR
PROVIDER: S-EPMC6736073 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Syphilis Reactivates Latent Epstein-Barr Virus Reservoir via Toll-Like Receptor 2 and B-Cell Receptor Activation.
Hirsiger Julia R JR Fuchs Philipp S PS Häusermann Peter P Müller-Durovic Bojana B Daikeler Thomas T Recher Mike M Hirsch Hans H HH Terracciano Luigi L Berger Christoph T CT
Open forum infectious diseases 20190703 9
Latent Epstein-Barr virus (EBV) infection can clinically reactivate in immunosuppressed individuals causing lymphoproliferative disease and rarely hepatitis. In this study, we provide in vivo and in vitro evidence that <i>Treponema pallidum</i> infection can cause EBV reactivation with hepatitis in an immunocompetent patient. We report the diagnostic challenges and immunological findings of coinciding syphilis and EBV-associated hepatitis. Using an in vitro EBV-reactivation assay, we demonstrate ...[more]
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