Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Q
PROVIDER: S-EPMC6736141 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhou Qing Q Pham Kieu T M KTM Hu Huiqing H Kurasawa Yasuhiro Y Li Ziyin Z
Nucleic acids research 20190901 15
DNA damage-induced cell cycle checkpoints serve as surveillance mechanisms to maintain genomic stability, and are regulated by ATM/ATR-mediated signaling pathways that are conserved from yeast to humans. Trypanosoma brucei, an early divergent microbial eukaryote, lacks key components of the conventional DNA damage-induced G2/M cell cycle checkpoint and the spindle assembly checkpoint, and nothing is known about how T. brucei controls its cell cycle checkpoints. Here we discover a kinetochore-bas ...[more]