Ontology highlight
ABSTRACT:
SUBMITTER: Lou JW
PROVIDER: S-EPMC6736866 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lou Jennifer W JW Iyer Kali R KR Hasan S M Naimul SMN Cowen Leah E LE Mazhab-Jafari Mohammad T MT
Scientific reports 20190910 1
During fatty acid biosynthesis, acyl carrier proteins (ACPs) from type I fungal fatty acid synthase (FAS) shuttle substrates and intermediates within a reaction chamber that hosts multiple spatially-fixed catalytic centers. A major challenge in understanding the mechanism of ACP-mediated substrate shuttling is experimental observation of its transient interaction landscape within the reaction chamber. Here, we have shown that ACP spatial distribution is sensitive to the presence of substrates in ...[more]