Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing.
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ABSTRACT:
SUBMITTER: Xue VW
PROVIDER: S-EPMC6736954 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing.
Xue Vivian W VW Cheung Moon T MT Chan Pak T PT Luk Lewis L Y LLY Lee Vivian H VH Au Thomas C TC Yu Allen C AC Cho William C S WCS Tsang Hin Fung Andy HFA Chan Amanda K AK Wong S C Cesar SCC
Scientific reports 20190910 1
We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value < 0.05. More detailed analysis showed that the expression of both ...[more]
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