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Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.


ABSTRACT: This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders. Genotyping of classic polymorphic sites for the ApoE (rs429358 and rs7412) and the ACE (rs4646994) genes used peripheral DNA. A total of 63% of the subjects reported poor quality of sleep assessed by the PSQI whereas 54 (33%) reported daytime sleepiness through the Epworth scale. A significant correlation was observed between APOE and PSQI, with a greater frequency of the poor nighttime sleep quality phenotype among ?2 carriers, whereas no correlation was found among any of the sleep scores and the ACE genotypes. Thus, we suggest a correlation between APOE alleles and scale-assessed sleep quality scores in older adults, with no implications for ACE alleles, in a context devoid of cognitive impairment.

SUBMITTER: Camargos EF 

PROVIDER: S-EPMC6737399 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.

Camargos Einstein F EF   Goncalves Isabela D ID   Bretones Luiza Al LA   Machado Marcela Fm MF   Morais-Junior Gilberto S GS   Brito Artur Fs AF   Henriques Adriane D AD   Morais Clayton F CF   Nóbrega Otávio T OT  

International journal of molecular epidemiology and genetics 20190815 4


This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epwo  ...[more]

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