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The evolving role of radiation therapy for resectable and unresectable gastric cancer.


ABSTRACT: Gastric cancer is a common malignancy worldwide, and treatment of localized disease has shifted from surgery alone to the addition of chemotherapy at various stages in treatment. The role of radiation in the management of gastric cancer has evolved significantly since the seminal publication of INT 0116 demonstrated a survival advantage to adjuvant chemoradiation. In this review, we summarize multiple landmark studies discussing the role of radiation in non-metastatic gastric cancer, both in resectable and unresectable patients. This review will additionally discuss the evidence for pre-operative chemoradiation, as the benefit has already been demonstrated in esophageal and rectal cancer.

SUBMITTER: Shinde A 

PROVIDER: S-EPMC6737448 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The evolving role of radiation therapy for resectable and unresectable gastric cancer.

Shinde Ashwin A   Novak Jennifer J   Amini Arya A   Chen Yi-Jen YJ  

Translational gastroenterology and hepatology 20190830


Gastric cancer is a common malignancy worldwide, and treatment of localized disease has shifted from surgery alone to the addition of chemotherapy at various stages in treatment. The role of radiation in the management of gastric cancer has evolved significantly since the seminal publication of INT 0116 demonstrated a survival advantage to adjuvant chemoradiation. In this review, we summarize multiple landmark studies discussing the role of radiation in non-metastatic gastric cancer, both in res  ...[more]

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