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Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling.

ABSTRACT: The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.

SUBMITTER: Della-Felice F 

PROVIDER: S-EPMC6737538 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling.

Della-Felice Franco F   Sarotti Ariel M AM   Krische Michael J MJ   Pilli Ronaldo A RA  

Journal of the American Chemical Society 20190821 35

The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members. ...[more]

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