Ontology highlight
ABSTRACT:
SUBMITTER: Niu S
PROVIDER: S-EPMC6737697 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Niu Shiwei S Williams Gareth R GR Wu Jianrong J Wu Junzi J Zhang Xuejing X Chen Xia X Li Shude S Jiao Jianlin J Zhu Li-Min LM
Journal of nanobiotechnology 20190910 1
<h4>Background</h4>It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.<h4>Results</h4>In this work, we develop a solution in the form of a cascade responsive nanoplatform based on thermo-sensitive poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) nanoparticles (NPs). These are further modified with the cell penetrating peptide (CPP) and loaded with the chemothe ...[more]