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A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy.


ABSTRACT: BACKGROUND:It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal. RESULTS:In this work, we develop a solution in the form of a cascade responsive nanoplatform based on thermo-sensitive poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) nanoparticles (NPs). These are further modified with the cell penetrating peptide (CPP) and loaded with the chemotherapeutic drug doxorubicin (DOX). The base copolymer was optimized to undergo a phase change at the elevated temperatures of the tumor microenvironment. The acid-responsive properties of CS provide a second trigger for drug release, and the inclusion of CPP should ensure the formulations accumulate in cancerous tissue. The resultant CPP-CS-co-PNVCL NPs could self-assemble in aqueous media into spherical NPs of size?

SUBMITTER: Niu S 

PROVIDER: S-EPMC6737697 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy.

Niu Shiwei S   Williams Gareth R GR   Wu Jianrong J   Wu Junzi J   Zhang Xuejing X   Chen Xia X   Li Shude S   Jiao Jianlin J   Zhu Li-Min LM  

Journal of nanobiotechnology 20190910 1


<h4>Background</h4>It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.<h4>Results</h4>In this work, we develop a solution in the form of a cascade responsive nanoplatform based on thermo-sensitive poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) nanoparticles (NPs). These are further modified with the cell penetrating peptide (CPP) and loaded with the chemothe  ...[more]

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