Dataset Information

High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study.

ABSTRACT:

Background

The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru.

Methods

A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n?=?136) and household contacts (n?=?138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed.

Results

In TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia.

Conclusion

High prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population.

SUBMITTER: Calderon RI

PROVIDER: S-EPMC6737721 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study.

Calderon Roger I RI Arriaga Maria B MB Lopez Kattya K Barreda Nadia N NN Sanabria Oswaldo M OM Fróes Neto José F JF Araújo Davi Neri DN Lecca Leonid L Andrade Bruno B BB

BMC infectious diseases 20190911 1

<h4>Background</h4>The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru.<h4>Methods</h4>A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucos ...[more]

PMID: 31510930

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Dataset Information

High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study.

Background

Methods

Results

Conclusion

Publications

High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study.

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