CE-MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer.

ABSTRACT:

Background

Prostate cancer progresses slowly when present in low risk forms but can be lethal when it progresses to metastatic disease. A non-invasive test that can detect significant prostate cancer is needed to guide patient management.

Methods

Capillary electrophoresis/mass spectrometry has been employed to identify urinary peptides that may accurately detect significant prostate cancer. Urine samples from 823 patients with PSA (<15 ng/ml) were collected prior to biopsy. A case-control comparison was performed in a training set of 543 patients (n_Sig = 98; n_non-Sig = 445) and a validation set of 280 patients (n_Sig = 48, n_non-Sig = 232). Totally, 19 significant peptides were subsequently combined by a support vector machine algori

SUBMITTER: Frantzi M 

PROVIDER: S-EPMC6738044 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature